This program trains Fellows in clinical and bench research as it relates to a variety of neuroimmune and virological disorders. Clinical research consists of natural history studies, development of novel biomarkers of disease activity, and therapeutic intervention using pharmacologic and biological approaches. Major emphasis is on clinical immunology and novel neuroradiological techniques. In addition to clinical rotations within the NIH Clinical Center, fellows will have the opportunity to rotate in affiliated academic centers including Georgetown University Hospital and Walter Reed National Military Medical Center. Bench research is largely focused on understanding disease pathophysiology but also includes novel pathogen discovery and drug development. The program has developed several disease models that include in vitro human brain models, iPS cells, rodent and simian models, and uses a variety of techniques such as intravital imaging, multicolor imaging flow cytometry, mass spectrometry and animal positron emission tomography (PET) and MRI scanning.