It is an image of dopaminergic neurons labeled with a red fluorescent protein in a horizontal mouse brain section. To the right is the midbrain where the dopaminergic neuron cell bodies are, and to the left is the striatum where the majority of the axons project to. In the middle are the axons passing from the midbrain to the striatum along the medial forebrain bundle.

Synapse-like axo-axonal communication

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Plot showing location of cryptic exon included in UNC13A RNA when TDP-43 levels are reduced in the nucleus of the cell.

Messy splicing of key synaptic gene drives ALS/FTD

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Messy splicing of key synaptic gene drives ALS/FTD

In rare myopathy, stressed mitochondria adapt to survive

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Structure of the external pore of wild-type Shaker-IR and the W434F mutant.

Shaker Kv channel revealed in new structure

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STAT1 mutations give deeper insight into cerebral aneurysms

STAT1 mutations give deeper insight into cerebral aneurysms

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Images depicting each of the 4 conditions: palm posture (top left), forward posture (bottom left), wingbeat (top right), and cup hold (bottom right). For each condition, the middle left and right-most pictures depict the left-only and right-only unimanual tasks, respectively, and the middle image depicts the bimanual task. Figure 1 from publication.

With essential tremor, two hands are better than one

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“Arbor Vitae,” colorized image from formalin fixed human cerebellum acquired at 100 micron isotropic resolution on the 11.7T MRI system. Image credit: Govind Nair Bhagavatheeshwaran), Staff Scientist in the qMRI Core Facility, and Stephen Dodd, Staff Scientist, at the Laboratory of Functional and Molecular Imaging.

See Some of the Latest Publications & News from NINDS Faculty

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graphic drawing of a green circle with a blue brain inside

About NINDS Division of Intramural Research

The present Intramural Research program of the National Institute of Neurological Disorders and Stroke (NINDS) began in the early 1950's with research programs in basic neuroscience, neurology and neurosurgery. Today investigators in the NINDS intramural program conduct research in the basic, translational, and clinical neurosciences at the NINDS Bethesda, Maryland laboratories.

Learn More About NINDS Intramural

Upcoming Events

Friday, August 12, 2022 | 11:00 - 4:00 PM
National Institute of Environmental Health Sciences (NIEHS) Exposomics Workshop Series.
Tuesday, August 16, 2022 | 1:00 - 2:00 PM
A career workshop on preparing for the industry job market
Friday, August 19, 2022 | 11:00 - 4:00 PM
Please join us at this pivotal moment to catalyze the shift from defining the exposome to doing it.