Single nucleus RNA-sequencing clustering of 66,432 nuclei, visualized as a uniform manifold approximation and projection (UMAP) plot, with a single dot for each nucleus colored to correspond to its cell-type cluster.

Cellular Blueprint of Chronic MS Lesions Reveals New Path to Therapies 

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Modified version of the graphical abstract summarizing key findings, schematizing Oligodendrocyte-to-neuron SIRT2 signaling and its effect on mitochondrial ATP production.

Oligodendrocyte-to-axon Signaling Enhances Axonal Bioenergetics

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Modified from Figure 3 of the publication, a visual representation of brain regions supporting replay events, identified through principal component analysis.

Why Short Breaks Help Us Learn

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Cover art for the July 26 issue of the journal Developmental Cell, featuring an artist’s interpretation of microtubule dynamics.

Microtubules: New Answers to an Old Mystery

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Florescent micrograph of SPTLC1-mutant motor-neuron-like cells differentiated from SPTLC1-mutant induced pluripotent stem cells, immunostained with relevant markers.

A New Genetic Form of ALS in Children

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Fluorescent STED images showing novel observation of transitions in membrane shape from flat surface to pinched-off vesicle.

New Chapter in Membrane Dynamics 

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Human stem cells expressing the HERV-K envelope protein. Credit: David Wang

Do retroviral genes help stem cells become neurons?

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neurons

Cerebellospinal Neurons Regulate Motor Performance and Motor Learning

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graphic drawing of a green circle with a blue brain inside

About NINDS Division of Intramural Research

The present Intramural Research program of the National Institute of Neurological Disorders and Stroke (NINDS) began in the early 1950's with research programs in basic neuroscience, neurology and neurosurgery. Today investigators in the NINDS intramural program conduct research in the basic, translational, and clinical neurosciences at the NINDS Bethesda, Maryland laboratories.

Learn More About NINDS Intramural

Upcoming Events

Monday, September 27, 2021 | 12:00 - 1:00 PM
Speaker: Dr. Shannon E. Boye, University of Florida
Monday, October 04, 2021 | 12:01 - 1:00 PM
Speaker: Dr. Michael Krashes, NIDDK/NIH
Monday, October 18, 2021 | 12:00 - 1:00 PM
Speaker: Dr. Sarah Woolley, Columbia University, Zuckerman Institute