Our research focuses on the biological abnormalities that underlie inherited neurodegenerative diseases, with a goal of translating new insights into effective therapies for affected patients. Using genetically-engineered iPSC derived neurons as experimental platforms, we study how disease-related gene mutations alter the function of molecular networks within cells. Our projects rely on a combination of ‘omics, molecular, biochemical, and imaging techniques.
Our lab is located in Pod 2A of the Porter Neuroscience Building at the National Institutes of Health in Bethesda, MD, the largest biomedical research campus in the United States.