Unlock the Epigenomic Secrets of CNS Tumors
Position type:
NIH Post-doc; Building 10, Bethesda, MD
Position description:
Join the Neurosurgery Unit for Pituitary and Inheritable Diseases at NIH in an exciting journey through the complex landscape of tumor biology and physiology. We are looking for highly motivated and passionate post-doctoral candidates interested in leveraging the power of state-of-the-art genomic techniques to uncover the secrets of mammalian pituitary gland and central nervous system (CNS) tumors.
Our collaborative and pioneering group has already made significant strides in the pathogenesis of pituitary adenomas (PMID: 36001971, PMID: 28505327, PMID: 28986303) and other CNS tumors (PMID: 37018064, PMID: 28094316).
Be part of our team as we map the transcriptional landscape of the post-natal human pituitary gland and delve into key pathogenic mechanisms underlying pituitary adenomas causing Cushing’s disease. Immerse yourself in rich datasets including bulk RNAseq, single cell/single nucleus RNAseq, single cell multiome, bulk methylation and genomic sequencing datasets for pituitary (normal and adenoma), schwannomas and other CNS tumors associated with neurofibromatosis type 2 (NF2) and von Hippel Lindau disease (VHL).
Core responsibilities:
As a valued member of our team, you will work closely with dedicated bioinformaticians, exploring richly annotated, existing datasets to extract key insights into post-natal canonical cell class states, tumor cell evolution, intra-tumoral and inter-tumoral heterogeneity, and genotype-phenotype associations in inheritable diseases (NF2 and VHL).
Your role will extend beyond analysis; you will design projects to investigate and validate findings mechanistically, spearheading specific projects and manuscripts. Enjoy a dynamic, collaborative environment with other bio-informaticians, a staff scientist, other post-docs, students, and clinicians.
Start date:
We are eager to welcome our new post-doc in the second half of 2023, but we are flexible with the start date for the right candidate.
Qualifications:
We seek applicants with a doctoral degree in molecular biology, tumor biology, endocrinology, or a related area. If you have experience in designing and implementing translational projects, we especially encourage you to apply. Prior experience with human derived primary cell cultures will be advantageous.
Stipends/benefits:
We believe in rewarding our post-docs for their efforts. The salary will be commensurate with experience, based on the NIH Postdoctoral Intramural Research Training Award and Visiting Fellow scale; medical insurance coverage will be provided. The position is renewable for up to five years.
To apply:
Excited to embark on this journey with us? Send a brief cover letter detailing your research and career goals, current curriculum vitae, and the names/contact information for three references to Prashant Chittiboina. Candidates will have the opportunity to interact with current lab members, core personnel, and the bioinformatics team.
Employer Name:
National Institute of Neurological Diseases and Stroke at Bethesda, MD
Application Deadline:
We encourage early application. The review of applications will begin immediately and will continue until the position is filled.
Disclaimer:
The NIH is dedicated to building a diverse community in its training and employment programs.