Animal Studies

Work in LFMI often makes use of animal models, especially rodents. This work is done in a manner that is consistent with all of the rules and regulations of the NINDS IACUC. Rodents are used for three types of studies:

  • Advancing non-invasive assessment of brain function using anatomical, functional, and molecular imaging techniques
  • Elucidating the regulation and control of cellular energy metabolism and the role of creatine kinase
  • Development of imaging techniques useful for analyzing transgenic mice to help with functional genomic studies
  • Understanding control of cerebral microcirculation
  • Establishing the marmoset as an animal modal for marmoset study of the brain

Active LFMI animal protocols

  • ASP 1142-09 - Imaging Brain Function in Rats and Mice
  • ASP 1160-10 - Imaging Brain Plasticity in Rats and Mice
  •  ASP 1321-10 - Manganese Based Radiotracers for PET Imaging in Rodents
  • 03-N-0142 - Development of 7 Tesla MRI Methodology for Anatomical Functional and Spectroscopic Imaging of the Brain
  • 05-N-0179 - MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle
  • ASP 1291-08 - Functional MRI in Awake Rodents
  • ASP 1199-11 - Breeding of Mice for Experiments in the LFMI

How to get started?

Work with animals in LFMI is done under the supervision of the NINDS IACUC and the NIH NMR Center Mouse Imaging Committee. For a detailed description of procedures that are followed prior to starting any animal studies in LFMI, please go to the NMRF web site.