Publications

  • Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature 524: 309-314, 2015.
  • Pickrell AM, Huang CH, Kennedy SR, Ordureau A, Sideris DP, Harper JW, Youle RJ. Endogenous Parkin preserves dopaminergic substantia nigral neurons following mitochondrial DNA mutagenic stress. Neuron 87: 371-381, 2015.
  • Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol. 205:143-53, 2014.
  • Yamano K, Fogel, AI, Wang C, van der Bliek A, Youle RJ. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. eLife 3:e01612, 2014.
  • Hasson SA, Kane LA, Yamano K, Huang C-H, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ. Genome-wide high-content RNAi screens identify regulators of Parkin upstream of mitophagy. Nature 504:291-295, 2013.
  • Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell. 22:320-333, 2012.
  • Edlich F, Banerjee S, Suzuki M, Arnoult D, Cleland M, Wang C, Neutzner A, Tjandra N, Youle RJ. Bcl-xL retrotranslocates Bax from mitochondria into the cytosol. Cell, 145: 104-116, 2011.