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Primary Publications at NINDS, NIH (2012-present)
Castellano D, Wu KW, Keramidas A, Lu W (2022) Shisa7-dependent regulation of GABAA receptor single-channel gating kinetics. Journal of Neuroscience (In press)
Wu KW, Han WY, Lu W (2022) Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity. PLOS Biology (In press)
Wu KW, Shepard RD, Castellano D, Tian Q, Dong LJ, Lu W (2021) Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors. Neuropsychopharmacology.
Wu KW, Castellano D, Tian Q, Lu W (2021) Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes. Cell Reports.
Wu KW, Han WY, Tian QJ, Li Y, Lu W (2021) Activity-and sleep-dependent regulation of tonic inhibition by Shisa7 Cell Reports.
Castellano D, Shepard RD, Lu W (2021) Looking for Novelty in an “Old” Receptor: Recent Advances Toward Our Understanding of GABAARs and Their Implications in Receptor Pharmacology. Frontiers in Neuroscience. (Review)
Wenyan Han, Ryan D. Shepard, Wei Lu (2020) Regulation of GABAARs by Transmembrane Accessory Proteins. Trends in Neurosciences. (Review)
Wenyan Han, Jun Li, Kenneth A. Pelkey, Saurabh Pandey, Xiumin Chen, Ya-Xian Wang, Kunwei Wu, Lihao Ge, Tianming Li, David Castellano, Chengyu Liu, Ling-gang Wu, Ronald S. Petralia, Joseph W. Lynch, Chris J. McBain, Wei Lu (2019) Shisa7 is a GABAA receptor auxiliary subunit controlling benzodiazepine actions. Science.
*Previewed by: Modulating anxiety and activity (2019) Science 11 Oct 2019.
*Discussed by Sciencedaily
Li J, Han WY, Wu KW, Li YP, Liu Q, Lu W (2019) A conserved tyrosine residue in the Slitrk3 carboxyl-terminus is critical for GABAergic synapse development. Front. Mol. Neurosci.
Jingjing Duan, Saurabh Pandey, Tianming Li, David Castellano, Xinglong Gu, Jun Li, Qingjun Tian and Wei Lu (2019) Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development. Front. Cellular. Neurosci.
Gu XL and Wei Lu (2018) Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters.
Wenyan Han, Huiqing Wang, Jun Li, Shizhong Zhang and Wei Lu (2017) Ferric Chelate Reductase 1 Like protein (FRRS1L) associates with dynein vesicles and regulates glutamatergic synaptic transmission. Front. Mol. Neurosci.
Li J, Han WY, Pelkey KA, Duan JJ, Mao X, Wang YX, Craig MT, Dong LJ, Petralia RS, McBain CJ, Lu W (2017) Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development. Neuron. *Previewed by: GABAergic Synaptogenesis: A Case for Cooperation (2017) Fritschy, Jean-Marc et al. Neuron.
*Recommended by F1000Prime
Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA and W Lu (2017) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry.
Lu W and Chen YL. (2017) Development of fast neurotransmitter synapses: General principle and recent progress. Brain Research Bulletin. (Editorial)
Mao X, Gu X, Lu W. (2017) GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons. Journal of Neurophysiology.
Lu W, Bromley-Coolidge S, Li J. (2016) Regulation of GABAergic synapse development by postsynaptic membrane proteins. Brain Research Bulletin. (Review)
Gu X, Mao X, Lussier MP, Hutchison MA, Zhou L, Hamra FK, Roche KW, Lu W. (2016) GSG1L suppresses AMPA receptor- mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications. PDF
Gu X, Zhou L, Lu W. (2016) An NMDA receptor-dependent mechanism underlies inhibitory synapse development. Cell Reports. PDF
Collaborative Publications at NINDS, NIH (2012-present)
Marta Mota Vieira, Thien A. Nguyen, Kunwei Wu, John D. BadgerII, Brett M. Collins, Victor Anggono, Wei Lu, Katherine W. Roche (2020) An Epilepsy-Associated GRIN2A Rare Variant Disrupts CaMKIIα Phosphorylation of GluN2A and NMDA Receptor Trafficking. Cell Reports Volume 32, Issue 9, 1 September 2020.
Saurabh Pandey, Namrata Ramsakha, Rohan Sharma, Ravinder Gulia, Prachi Ojha, Wei Lu, Samarjit Bhattacharyya. (2020) The post-synaptic scaffolding protein Tamalin regulates ligand-mediated trafficking of metabotropic glutamate receptors. Journal of Biological Chemistry.
Thien A Nguyen , Kunwei Wu, Saurabh Pandey, Alexander W Lehr, Yan Li, Michael A Bemben, John D Badger 2nd, Julie L Lauzon, Tongguang Wang, Kareem A Zaghloul , Audrey Thurm, Mahim Jain, Wei Lu, Katherine W Roche. (2020) A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y. Neuron.
Lin Luo, Mateusz C. Ambrozkiewizc, Fritz Benseler, Cui Chen, Emilie Dumontier, Susanne Falkner , Elisabetta Furlanis, Andrea M. Gomez, Naosuke Hoshina, Wei-Hsiang Huang , Mary Anne Hutchison, Yu Itoh-Maruoka, Laura A. Lavery, Wei Li, Tomohiko Maruo, Junko Motohashi, Emily Ling-Lin Pai, Kenneth A. Pelkey, Ariane Pereira,Thomas Phillips, Jennifer Sinclair, Jeff Stogsdill, Lisa Traunmüller, Jiexin Wang, Joke Wortel, Wenjia You, Nashat Abumaria, Kevin T. Beier, Harold Burgess, Constance L. Cepko, Jean-François Cloutier, Cagla Eroglu, Sandra Goebbels, Pascal S. Kaeser, Jeremy N. Kay, Wei Lu, Liqun Luo, Kenji Mandai, Chris J. McBain, Klaus-Armin Nave, Marco A.M. Prado, Vania F. Prado, Jeffrey Rothstein, John L. R. Rubenstein, Gesine Saher, Kenji Sakimura, Joshua R. Sanes, Peter Scheiffele, Yoshimi Takai, Hisashi Umemori, Matthijs Verhage, Michisuke Yuzaki, Huda Yahya Zoghbi, Hiroshi Kawabe, Ann Marie Craig. (2020) Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron.
Jaehoon Jeong, Saurabh Pandey, Yan Li, John D. Badger II, Wei Lu, and Katherine W. Roche (2019) PSD-95 binding dynamically regulates NLGN1 trafficking and function. PNAS.
Tonghui Su, Yi Lu, Yang Geng, Wei Lu, Yelin Chen (2019) How could N-Methyl-D-Aspartate Receptor Antagonists Lead to Excitation Instead of Inhibition? Brain Science Advances.
Chia-Yu Yeh, Brent Asrican, Jonathan Moss, Luis Jhoan Quintanilla, Ting He, Xia Mao, Frederic Cassé, Elias Gebara, Hechen Bao, Wei Lu, Nicolas Toni, Juan Song (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron.
Thomas Steinkellner, Vivien Zell, Zachary J. Farino, Mark S. Sonders, Michael Villeneuve, Robin J. Freyberg, Serge Przedborski, Wei Lu, Zachary Freyberg, and Thomas S. Hnasko (2018) Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. Journal of Clinical Investigation.
Shuxi Liu, Liang Zhou, Hongjie Yuan, Marta Vieira, Antonio Sanz-Clemente, John D. Badger, Wei Lu, Stephen F. Traynelis and Katherine W. Roche. (2017) A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density. Journal of Neuroscience, 0827-16.
RM Lomash, X Gu, RJ Youle, W Lu, KW Roche. (2015) Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. Cell reports 12 (5), 743-751.
MP Lussier, X Gu, W Lu, KW Roche. (2014) Casein kinase 2 phosphorylates GluA1 and regulates its surface expression. European Journal of Neuroscience 39 (7), 1148-1158.
Publications from PhD (NYU SOM) and Postdoctoral research (UCSF) (2001-2011)
Lu W, Bushong EA, Shih TP, Ellisman MH, Nicoll RA (2013) The cell-autonomous role of excitatory synaptic transmission in the regulation of neuronal structure and function. Neuron. 2013 May 8;78(3):433-9.
Granger AJ, Shi Y, Lu W, Cerpas M, Nicoll RA (2013) LTP requires a reserve pool of glutamate receptors independent of subunit type. Nature. Jan 24; 493(7433): 495-500.
Lu W, Roche KW. (2012) Posttranslational regulation of AMPA receptor trafficking and function. Curr Opin Neurobiol. Jun;22(3):470-9.
Lu W, Gray JA, Granger AJ, During MJ and Nicoll RA. (2011) Potentiation of synaptic AMPA receptors induced by the deletion of NMDA receptors requires the GluA2 subunit. Journal of Neurophysiology. Feb;105(2):923-8.
Lu W, Isozaki K, Roche KW, Nicoll RA. (2010) Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. PNAS. Dec 21;107(51):22266-71.
Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH. (2010) Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron. 65, 66-79.
Shi Y, Lu W, Milstein AD, Nicoll RA. (2009) The stoichiometry of AMPA receptors and TARPs varies by neuronal cell types. Neuron. 62, 633-640.
Lu W, Shi Y, Jackson AC, Bjorgan K, During MJ, Sprengel R, Seeburg PH, Nicoll RA. (2009) Subunit composition of synaptic AMPA receptors revealed by a single-cell genetic approach. Neuron 62, 254-268.
Morishita W, Lu W (co-first author), Smith GB, Nicoll RA, Bear MF, Malenka RC. (2007) Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology. Jan; 52(1):71-6.
Lu W, Khatri L, Ziff EB (2014) Trafficking of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptor (AMPA) Receptor Subunit GluA2 from the Endoplasmic Reticulum Is Stimulated by a Complex Containing Ca2+/Calmodulin- activated Kinase II (CaMKII) and PICK1 Protein and by Release of Ca2+ from Internal Stores. Journal of Biological Chemistry 289 (27), 19218-19230
Silverman JB, Restituito S, Lu W, Lee-Edwards L, Khatri L, Ziff EB. (2007) Synaptic anchorage of AMPA receptors by cadherins through neural plakophilin-related arm protein AMPA receptor-binding protein complexes. J Neuroscience. Aug 8;27(32):8505-16.
Lu W and Ziff EB. (2005). PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking. Neuron 47, 407-421.