Our Team

Principal Investigator


Image
Dr. Yi Gu

Dr. Yi Du

Dr. Gu received her B.S. and M.S. degrees from Tsinghua University, and Ph.D. degree from Johns Hopkins University. Her Ph.D. work in Dr. Richard Huganir’s laboratory was focused on the molecular and cellular regulation of neurotransmitter receptor trafficking. Dr. Gu was trained as a postdoctoral fellow in the laboratory of Dr. David Tank at Princeton University, where she investigated the functional mechanism of the medial entorhinal cortex during spatial navigation by combining in vivo imaging with virtual reality behavioral paradigms. Dr. Gu joined NINDS as an investigator in 2019. Her research aims to understand the neural basis of spatial navigation and memory.

 

Postdocs


Image
Dr. Nai-Wen Tien

Dr. Nai-Wen Tien

Nai-Wen received her Ph.D. for work on function and development of mouse retinal circuits in Dr. Daniel Kerschensteiner’s lab at Washington University in St. Louis. Afterwards she transitioned to system neuroscience and joined Dr. Shaul Druckmann’s lab at Stanford University, working on several collaborative projects studying brain-wide activity for short-term memory. As a human being with terrible sense of direction, Nai-Wen always wonders if she has dysfunctional brain circuits for spatial navigation. To understand the potential reasons for her impaired internal GPS system, she joins Dr. Gu Yi’s lab working on the mechanisms underlying spatial learning and memory. Apart from working on research projects, she enjoys playing board games (especially Betrayal at House on the Hill!) and plans to finish a best-selling Sci-Fi novel about neuroscience.

Image
Dr. Taylor Malone

Dr. Taylor Malone

Taylor received his B.S. in Biology and Biomedical Engineering Systems from Tufts University, before beginning his Ph.D. in Molecular and Cellular Physiology at Yale University in the laboratory of Leonard Kaczmarek. In the Kaczmarek lab, Taylor studied Slack potassium channels and their gain-of-function mutations leading to childhood epilepsy and intellectual disability. Taylor characterized a novel mechanism by which activation, or gain-of-function mutation, of Slack channels regulates mRNA translation. In the Gu lab, Taylor is pursuing his interest in understanding the mechanisms behind neurological disease by studying the role of the medial entorhinal cortex (MEC) in spatial learning and memory and MEC dysfunction in Alzheimer’s disease. Taylor’s hobbies include hiking, baking, and reading science fiction.

 

Postbacs


Image
Duc Nguyen

Duc Nguyen

Duc received Bachelor's degree in Psychology from the University of California Berkeley. He joined the lab in August 2020 and is currently working on how sensory information is represented in the medial entorhinal cortex (MEC) during spatial navigation. He's leaving the lab in August 2022 for NYU where he will begin his PhD in Neuroscience.

 

 

 

Image
Garret Wang

Garret Wang

Garret has a bachelor's degree in biology from the University of California, San Diego. He joined the lab in June 2022 to study spatial processing neural networks in mice within virtual environments. While working with Yi Gu, he plans to foster the skills necessary for careers in research and medicine. In his free time, Garret enjoys music, reading, and creative writing.

 

 

Image
Jean Tyan

Jean Tyan

Jean received her M.H.S. in Epidemiology from the Johns Hopkins Bloomberg School of Public Health, where she investigated relationships between discriminatory experiences, epigenetic aging, and dementia under the guidance of Dr. Aisha Dickerson. Prior to this, she earned her B.S. in Biology and Biopsychology, Cognition, and Neuroscience from the University of Michigan. There, she studied the role of pre-sleep behaviors in sleep quality and sleep physiology in the lab of Dr. Ada Eban-Rothschild. In the Gu lab, she will join Taylor Malone in examining the dysfunction of the medial entorhinal cortex in Alzheimer's disease. Jean intends to pursue a Ph.D. to bridge basic science and population-level epidemiologic findings to alleviate health disparities in Alzheimer's disease. Outside the lab, she loves to play the flute and enjoys classical music.