Inactivation of the Kv2.1 channel through electromechanical coupling.

Fernández-Mariño AI, Tan XF, Bae C, Huffer K, Jiang J, Swartz KJ.

 Nature. 2023 Oct;622(7982):410-417. doi: 10.1038/s41586-023-06582-8. Epub 2023 Sep 27.

PMID: 37758949 Free PMC article.


Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing.

Ballesteros A, Swartz KJ.

Sci Adv. 2022 Aug 5;8(31):eabm5550. doi: 10.1126/sciadv.abm5550. Epub 2022 Aug 3.

PMID: 35921424 Free PMC article.


Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.

Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR.

Nat Commun. 2022 Jul 4;13(1):3854. doi: 10.1038/s41467-022-31285-5.

PMID: 35788586 Free PMC article.


Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.

Tan XF, Bae C, Stix R, Fernández-Mariño AI, Huffer K, Chang TH, Jiang J, Faraldo-Gómez JD, Swartz KJ.

Sci Adv. 2022 Mar 18;8(11):eabm7814. doi: 10.1126/sciadv.abm7814. Epub 2022 Mar 18.

PMID: 35302848 Free PMC article.


Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms.

Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ.

Elife. 2020 Aug 17;9:e58660. doi: 10.7554/eLife.58660.

PMID: 32804077 Free PMC article.


The ion selectivity filter is not an activation gate in TRPV1-3 channels.

Jara-Oseguera A, Huffer KE, Swartz KJ.

Elife. 2019 Nov 14;8:e51212. doi: 10.7554/eLife.51212.

PMID: 31724952 Free PMC article.


Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.

Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ.

Elife. 2019 Jun 24;8:e47060. doi: 10.7554/eLife.47060.

PMID: 31232692 Free PMC article.


Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity.

Zhang F, Swartz KJ, Jara-Oseguera A.

Elife. 2019 Jan 15;8:e42756. doi: 10.7554/eLife.42756.

PMID: 30644819 Free PMC article.


Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins.

Ballesteros A, Fenollar-Ferrer C, Swartz KJ.

Elife. 2018 Jul 31;7:e38433. doi: 10.7554/eLife.38433.

PMID: 30063209 Free PMC article.


Lipids surf the groove in scramblases.

Ballesteros A, Swartz KJ.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7648-7650. doi: 10.1073/pnas.1809472115. Epub 2018 Jul 6.

PMID: 29980647 Free PMC article. No abstract available.


TRPM channels come into focus.

Bae C, Jara-Oseguera A, Swartz KJ.

Science. 2018 Jan 12;359(6372):160-161. doi: 10.1126/science.aar6205.

PMID: 29326261 No abstract available.


Heat activation is intrinsic to the pore domain of TRPV1.

Zhang F, Jara-Oseguera A, Chang TH, Bae C, Hanson SM, Swartz KJ.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E317-E324. doi: 10.1073/pnas.1717192115. Epub 2017 Dec 26.

PMID: 29279388 Free PMC article.


STRUCTURAL BIOLOGY. Twists and turns in gating ion channels with voltage.

Toombes GE, Swartz KJ.

Science. 2016 Aug 12;353(6300):646-7. doi: 10.1126/science.aah4194.

PMID: 27516583 No abstract available.

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