Publications

Inactivation of the Kv2.1 channel through electromechanical coupling.

Fernández-Mariño AI, Tan XF, Bae C, Huffer K, Jiang J, Swartz KJ.

 Nature. 2023 Oct;622(7982):410-417. doi: 10.1038/s41586-023-06582-8. Epub 2023 Sep 27.

PMID: 37758949 Free PMC article.

2.

Regulation of membrane homeostasis by TMC1 mechanoelectrical transduction channels is essential for hearing.

Ballesteros A, Swartz KJ.

Sci Adv. 2022 Aug 5;8(31):eabm5550. doi: 10.1126/sciadv.abm5550. Epub 2022 Aug 3.

PMID: 35921424 Free PMC article.

3.

Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.

Selvakumar P, Fernández-Mariño AI, Khanra N, He C, Paquette AJ, Wang B, Huang R, Smider VV, Rice WJ, Swartz KJ, Meyerson JR.

Nat Commun. 2022 Jul 4;13(1):3854. doi: 10.1038/s41467-022-31285-5.

PMID: 35788586 Free PMC article.

4.

Structure of the Shaker Kv channel and mechanism of slow C-type inactivation.

Tan XF, Bae C, Stix R, Fernández-Mariño AI, Huffer K, Chang TH, Jiang J, Faraldo-Gómez JD, Swartz KJ.

Sci Adv. 2022 Mar 18;8(11):eabm7814. doi: 10.1126/sciadv.abm7814. Epub 2022 Mar 18.

PMID: 35302848 Free PMC article.

5.

Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms.

Huffer KE, Aleksandrova AA, Jara-Oseguera A, Forrest LR, Swartz KJ.

Elife. 2020 Aug 17;9:e58660. doi: 10.7554/eLife.58660.

PMID: 32804077 Free PMC article.

6.

The ion selectivity filter is not an activation gate in TRPV1-3 channels.

Jara-Oseguera A, Huffer KE, Swartz KJ.

Elife. 2019 Nov 14;8:e51212. doi: 10.7554/eLife.51212.

PMID: 31724952 Free PMC article.

7.

Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP.

Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gómez JD, Hattori M, Swartz KJ.

Elife. 2019 Jun 24;8:e47060. doi: 10.7554/eLife.47060.

PMID: 31232692 Free PMC article.

8.

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity.

Zhang F, Swartz KJ, Jara-Oseguera A.

Elife. 2019 Jan 15;8:e42756. doi: 10.7554/eLife.42756.

PMID: 30644819 Free PMC article.

9.

Structural relationship between the putative hair cell mechanotransduction channel TMC1 and TMEM16 proteins.

Ballesteros A, Fenollar-Ferrer C, Swartz KJ.

Elife. 2018 Jul 31;7:e38433. doi: 10.7554/eLife.38433.

PMID: 30063209 Free PMC article.

10.

Lipids surf the groove in scramblases.

Ballesteros A, Swartz KJ.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7648-7650. doi: 10.1073/pnas.1809472115. Epub 2018 Jul 6.

PMID: 29980647 Free PMC article. No abstract available.

11.

TRPM channels come into focus.

Bae C, Jara-Oseguera A, Swartz KJ.

Science. 2018 Jan 12;359(6372):160-161. doi: 10.1126/science.aar6205.

PMID: 29326261 No abstract available.

12.

Heat activation is intrinsic to the pore domain of TRPV1.

Zhang F, Jara-Oseguera A, Chang TH, Bae C, Hanson SM, Swartz KJ.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E317-E324. doi: 10.1073/pnas.1717192115. Epub 2017 Dec 26.

PMID: 29279388 Free PMC article.

13.

STRUCTURAL BIOLOGY. Twists and turns in gating ion channels with voltage.

Toombes GE, Swartz KJ.

Science. 2016 Aug 12;353(6300):646-7. doi: 10.1126/science.aah4194.

PMID: 27516583 No abstract available.