Publications

Lim S, Kwak M, Kang J, Cesaire M, Tang K, Robey RW, Frye WJE, Karim B, Butcher D, Lizak MJ, Dalmage M, Foster B, Nuechterlein N, Eberhart C, Cimino PJ, Gottesman MM, Jackson S (2024)
Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model.
Acta Neuropathol Commun, 12:56. PubMed ID: 38589905

In The News

Classifying Brain and Spine Tumors More Precisely to Improve Patient Outcomes and Care

 

Select Publications

2024


Thirimanne HN, Almiron-Bonnin D, Nuechterlein N, Arora S, Jensen M, Parada CA, Qiu C, Szulzewsky F, English CW, Chen WC, Sievers P, Nassiri F, Wang JZ, Klisch TJ, Aldape KD, Patel AJ, Cimino PJ, Zadeh G, Sahm F, Raleigh DR, Shendure J, Ferreira M, Holland EC (2024)
Meningioma transcriptomic landscape demonstrates novel subtypes with regional associated biology and patient outcome.
Cell Genom,:100566. PubMed ID: 38788713

Nuechterlein N, Shelbourn A, Szulzewsky F, Arora S, Casad M, Pattwell S, Merino-Galan L, Sulman E, Arowa S, Alvinez N, Jung M, Brown D, Tang K, Jackson S, Stoica S, Chittaboina P, Banasavadi-Siddegowda YK, Wirsching HG, Stella N, Shapiro L, Paddison P, Patel AP, Gilbert MR, Abdullaev Z, Aldape K, Pratt D, Holland EC, Cimino PJ (2024)
Haploinsufficiency of phosphodiesterase 10A activates PI3K/AKT signaling independent of PTEN to induce an aggressive glioma phenotype.
Genes Dev, PubMed ID: 38589034

Andreiuolo F, Ferrone CK, Rajan S, Perry A, Guney E, Cham E, Giannini C, Toland A, Willard N, de Souza AS, Dazelle K, Chung HJ, Singh O, Conway K, Coley N, Dampier C, Abdullaev Z, Pratt D, Cimino PJ, Quezado M, Aldape K (2024)
Molecular and clinicopathologic characteristics of CNS embryonal tumors with BRD4::LEUTX fusion.
Acta Neuropathol Commun, 12:42. PubMed ID: 38500181

Donev K, Sundararajan V, Johnson D, Balan J, Chambers M, Paulson VA, Scherpelz KP, Abdullaev Z, Quezado M, Cimino PJ, Pratt D, Valerio E, Alves de Castro JV, Carraro DM, Torrezan GT, Wolff BM, Kulikowski LD, Costa FD, Aldape K, Ida CM (2024)
Diffuse hemispheric glioma with H3 p.K28M (K27M) mutation: Unusual non-midline presentation of diffuse midline glioma, H3 K27M-altered?
J Neuropathol Exp Neurol, PubMed ID: 38447592

2023


Yoda RA, Cimino PJ (2023)
Classification and Grading of Central Nervous System Tumors According to the World Health Organization 5th Edition.
Semin Neurol, PubMed ID: 37949117

Shelbourn A, Nuechterlein N, Parada CA, Eaton J, Tucker M, Ferreira M, Cimino PJ (2023)
Validating MCM2 as a clinically relevant surrogate immunohistochemical marker for an aggressive meningioma molecular subtype.
J Neuropathol Exp Neurol, PubMed ID: 37837323

Wirsching HG, Felsberg J, Prummer M, Moisoiu V, Lourman R, Hertler C, Antonios M, Cimino PJ, Roth P, Gorlia T, Prins RM, Cloughesy T, Wen PY, Holland EC, Reifenberger G, Weller M (2023)
Spatial immune profiling of glioblastoma identifies an inflammatory, perivascular phenotype associated with longer survival.
Acta Neuropathol, PubMed ID: 37573572

Chatzopoulos K, Hytiroglou P, Charville GW, Toland AMS, Martinez-Lage M, Cimino PJ, Rosenblum MK, Linos K (2023)
When a dermatopathologist encounters the ultra-rare: A case series of superficial soft tissue/cutaneous myxopapillary ependymomas.
J Cutan Pathol, PubMed ID: 37317818

Elmuti L, Amundson J, Oberman E, Kamat A, Sedig L, Lastra RR, Aldape K, Quezado M, Pratt DW, Cimino PJ, Abdullaev Z, Pytel P, Applebaum MA, Bennett JA (2023)
Diffuse Pediatric-type High-grade Glioma Arising in an Ovarian Mature Cystic Teratoma.
Int J Gynecol Pathol, PubMed ID: 37046379

Kim Y, Danaher P, Cimino PJ, Hurth K, Warren S, Glod J, Beechem JM, Zada G, McEachron TA (2023)
Highly Multiplexed Spatially Resolved Proteomic and Transcriptional Profiling of the Glioblastoma Microenvironment Using Archived Formalin-Fixed Paraffin-Embedded Specimens.
Mod Pathol, 36:100034. PubMed ID: 36788070

Liu Y, Chou FJ, Lang F, Zhang M, Song H, Zhang W, Davis DL, Briceno NJ, Zhang Y, Cimino PJ, Zaghloul KA, Gilbert MR, Armstrong TS, Yang C (2023)
Protein kinase B (PKB/AKT) protects IDH-mutated glioma from ferroptosis via Nrf2.
Clin Cancer Res, PubMed ID: 36648507

2022 


Cimino PJ, Ketchum C, Turakulov R, Singh O, Abdullaev Z, Giannini C, Pytel P, Lopez GY, Colman H, Nasrallah MP, Santi M, Fernandes IL, Nirschl J, Dahiya S, Neill S, Solomon D, Perez E, Capper D, Mani H, Caccamo D, Ball M, Badruddoja M, Chkheidze R, Camelo-Piragua S, Fullmer J, Alexandrescu S, Yeaney G, Eberhart C, Martinez-Lage M, Chen J, Zach L, Kleinschmidt-DeMasters BK, Hefti M, Lopes MB, Nuechterlein N, Horbinski C, Rodriguez FJ, Quezado M, Pratt D, Aldape K (2022)
Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1.
Acta Neuropathol, PubMed ID: 36271929

Pattwell SS, Arora S, Nuechterlein N, Zager M, Loeb KR, Cimino PJ, Holland NC, Reche-Ley N, Bolouri H, Almiron Bonnin DA, Szulzewsky F, Phadnis VV, Ozawa T, Wagner MJ, Haffner MC, Cao J, Shendure J, Holland EC (2022)
Oncogenic role of a developmentally regulated NTRK2 splice variant.
Sci Adv, 8:eabo6789. PubMed ID: 36206341

Wu Z, Rajan S, Chung HJ, Raffeld M, Panneer Selvam P, Schweizer L, Perry A, Samuel D, Giannini C, Ragunathan A, Frosch MP, Marshall MS, Boué DR, Donev K, Neill SG, Fernandes I, Resnick A, Rood B, Cummings TJ, Buckley AF, Szymanski L, Neto OLA, Zach L, Colman H, Cheshier S, Ziskin J, Tyagi M, Capper D, Abdullaev Z, Cimino PJ, Quezado M, Pratt D, Aldape K (2022)
Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions.
Acta Neuropathol, PubMed ID: 36201019

Szulzewsky F, Arora S, Arakaki AKS, Sievers P, Almiron Bonnin DA, Paddison PJ, Sahm F, Cimino PJ, Gujral TS, Holland EC (2022)
Both YAP1-MAML2 and constitutively active YAP1 drive the formation of tumors that resemble NF2 mutant meningiomas in mice.
Genes Dev, PubMed ID: 36008139

Park JH, Feroze AH, Emerson SN, Mihalas AB, Keene CD, Cimino PJ, de Lomana ALG, Kannan K, Wu WJ, Turkarslan S, Baliga NS, Patel AP (2022)
A single-cell based precision medicine approach using glioblastoma patient-specific models.
NPJ Precis Oncol, 6:55. PubMed ID: 35941215

Dai J, Cimino PJ, Gouin KH, Grzelak CA, Barrett A, Lim AR, Long A, Weaver S, Saldin LT, Uzamere A, Schulte V, Clegg N, Pisarsky L, Lyden D, Bissell MJ, Knott S, Welm AL, Bielas JH, Hansen KC, Winkler F, Holland EC, Ghajar CM (2022)
Astrocytic laminin-211 drives disseminated breast tumor cell dormancy in brain.
Nat Cancer, 3:25-42. PubMed ID: 35121993

2021


Nuechterlein N, Shapiro LG, Holland EC, Cimino PJ (2021)
Machine learning modeling of genome-wide copy number alteration signatures reliably predicts IDH mutational status in adult diffuse glioma.
Acta Neuropathol Commun, 9:191. PubMed ID: 34863298

Wu SJ, Furlan SN, Mihalas AB, Kaya-Okur HS, Feroze AH, Emerson SN, Zheng Y, Carson K, Cimino PJ, Keene CD, Sarthy JF, Gottardo R, Ahmad K, Henikoff S, Patel AP (2021)
Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression.
Nat Biotechnol, 39:819-824. PubMed ID: 33846646

Nuechterlein N, Li B, Feroze A, Holland EC, Shapiro L, Haynor D, Fink J, Cimino PJ (2021)
Radiogenomic modeling predicts survival-associated prognostic groups in glioblastoma.
Neurooncol Adv, 3:vdab004. PubMed ID: 33615222

2019


Yoda RA, Marxen T, Longo L, Ene C, Wirsching HG, Keene CD, Holland EC, Cimino PJ (2019)
Mitotic Index Thresholds Do Not Predict Clinical Outcome for IDH-Mutant Astrocytoma.
J Neuropathol Exp Neurol, 78:1002-1010. PubMed ID: 31529048

Cimino PJ, Holland EC (2019)
Targeted copy number analysis outperforms histologic grading in predicting patient survival for WHO grades II/III IDH-mutant astrocytomas.
Neuro Oncol, 21:819-821. PubMed ID: 30918961

2018


Cimino PJ, McFerrin L, Wirsching HG, Arora S, Bolouri H, Rabadan R, Weller M, Holland EC (2018)
Copy number profiling across glioblastoma populations has implications for clinical trial design.
Neuro Oncol, 20:1368-1373. PubMed ID: 29982740

Puchalski RB, Shah N, Miller J, Dalley R, Nomura SR, Yoon JG, Smith KA, Lankerovich M, Bertagnolli D, Bickley K, Boe AF, Brouner K, Butler S, Caldejon S, Chapin M, Datta S, Dee N, Desta T, Dolbeare T, Dotson N, Ebbert A, Feng D, Feng X, Fisher M, Gee G, Goldy J, Gourley L, Gregor BW, Gu G, Hejazinia N, Hohmann J, Hothi P, Howard R, Joines K, Kriedberg A, Kuan L, Lau C, Lee F, Lee H, Lemon T, Long F, Mastan N, Mott E, Murthy C, Ngo K, Olson E, Reding M, Riley Z, Rosen D, Sandman D, Shapovalova N, Slaughterbeck CR, Sodt A, Stockdale G, Szafer A, Wakeman W, Wohnoutka PE, White SJ, Marsh D, Rostomily RC, Ng L, Dang C, Jones A, Keogh B, Gittleman HR, Barnholtz-Sloan JS, Cimino PJ, Uppin MS, Keene CD, Farrokhi FR, Lathia JD, Berens ME, Iavarone A, Bernard A, Lein E, Phillips JW, Rostad SW, Cobbs C, Hawrylycz MJ, Foltz GD (2018)
An anatomic transcriptional atlas of human glioblastoma.
Science, 360:660-663. PubMed ID: 29748285

Cimino PJ, Kim Y, Wu HJ, Alexander J, Wirsching HG, Szulzewsky F, Pitter K, Ozawa T, Wang J, Vazquez J, Arora S, Rabadan R, Levine R, Michor F, Holland EC (2018)
Increased HOXA5 expression provides a selective advantage for gain of whole chromosome 7 in IDH wild-type glioblastoma.
Genes Dev, 32:512-523. PubMed ID: 29632085

2017


Cimino PJ, Zager M, McFerrin L, Wirsching HG, Bolouri H, Hentschel B, von Deimling A, Jones D, Reifenberger G, Weller M, Holland EC (2017)
Multidimensional scaling of diffuse gliomas: application to the 2016 World Health Organization classification system with prognostically relevant molecular subtype discovery.
Acta Neuropathol Commun, 5:39. PubMed ID: 28532485