BG 10 RM 9N311
10 CENTER DR
BETHESDA MD 20814
An investigator with NIDDK, Dr. Narayan maintains a joint appointment with NINDS.
Visit the Lab Webpage
- Postdoctoral Fellow, Whitehead Institute/MIT, 2013-2020
- Ph.D., University of Cambridge, 2012
- B.S., Stanford University, 2008
Neurodegenerative diseases like Alzheimer’s disease are a growing public health concern. The extended and devastating course of these diseases, the increasing patient population, and the lack of therapeutic options all contribute to this pressing public health crisis. Our lab studies the ways in which genetic and environmental factors alter fundamental cellular pathways to increase susceptibility or improve resilience to neurodegenerative diseases like Alzheimer’s disease. We are pursuing these scientific questions with the ultimate goal of identifying novel therapeutic or preventative mechanisms for neurodegenerative diseases. Our research combines techniques from biochemistry, genetic screening, and neurobiology in human induced pluripotent stem cell-derived tissues.
POSTDOCTORAL FELLOWS
POST-BACCALAUREATE FELLOWS
STAFF
Selected publications are below, for full list see Google Scholar.
- Sienski, G.*, Narayan, P.*, Bonner, J.M.*, Kory, N., Boland, S., Arczewska, A.A., Ralvenius, W.T., Akay., L.A., Lockshin, E., He, L., Milo, B., Graziosi, A., Baru, V., Lewis, C.A., Kellis, M. Sabatini, D.M., Tsai., L-H., Lindquist, S., APOE4 disrupts intracellular lipid homeostasis, Science Translational Medicine (2021) pdf
- Narayan, P.*, Sienski, G.*, Lin, Y-T., Seo, J., Bonner, J.M., Baru, V., Haque, A., Milo, B., Akay, L.A., Graziosi, A., Freyzon, Y., Landgraf, D., Hesse, W.R., Valastyan, J., Barrasa, M.I., Tsai., L-H., Lindquist, S., PICALM rescues endocytic defects caused by APOE4, Cell Reports (2020) pdf
- Ganzinger, K.A.*, Narayan, P.*, Qamar, S.S., Weimann, L., Ranasinghe, R.T., Aguzzi, A., Dobson, C.M., McColl, J., St George-Hyslop, P., Klenerman, D., Single-molecule imaging reveals that small amyloid-β1–42 oligomers interact with the cellular prion protein (PrPC), ChemBioChem (2014) pdf
- Narayan, P.*, Ehsani, S.*, Lindquist, S. Combating neurodegenerative disease using chemical probes and model systems. Nature Chemical Biology (2014) pdf
- Narayan, P.*, Holmstrom, K.M.*, Kim, D.H., Whitcomb, D.J., Wilson, M.R., Wood, N.W., Dobson, C.M., Cho, K., Abramov, A.Y., Klenerman, D., Rare individual amyloid-β oligomers act on astrocytes to initiate neuronal damage, Biochemistry (2014) pdf
- Narayan, P.*, Ganzinger, K.A.*, McColl, J.T., Qamar, S., St. George-Hyslop, P.G., Dobson C.,M., Klenerman, D., Single molecule imaging of the interaction between amyloid-β peptides and the membranes of hippocampal cells, Journal of the American Chemical Society (2013) pdf
- Narayan, P., Orte, A., Clarke, R.W., Bolognesi, B., Hook, S., Ganzinger, K.A., Meehan, S., Wilson, M.R., Dobson, C.M., Klenerman, D., The extracellular chaperone clusterin sequesters oligomeric forms of the Alzheimer’s disease-associated Aβ1-40 peptide, Nature Structural and Molecular Biology (2012) pdf
- Narayan, P., Meehan, S., Carver, J.A., Wilson, M.R., Dobson, C.M., Klenerman, D., Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones, Biochemistry (2012) pdf