Dr. Ariane Soldatos is Director of the NINDS Pediatric Neurology consultation service. Dr Soldatos earned her medical degree from McGill University in Montreal, Canada. She then completed her residency in pediatrics at McMaster University. She pursued a diploma in tropical medicine at the London School of Hygiene and Tropical Medicine in the UK. She went on to Boston Children’s Hospital for her pediatric neurology training. She then did a two-year fellowship in Neuro-infectious diseases at Boston Children’s Hospital and Massachusetts General Hospital.
She obtained a Master’s in Public Health at the Harvard School of Public Health. She came to the NIH Clinical Center in 2012 with initial inter-institute appointment between NINDS and the National Human Genome Research Institute (NHGRI)’s Undiagnosed Diseases Program. Dr. Soldatos has received an NIH Director’s Award in 2015, an NINDS Merit Award and a NHGRI Director’s Award in 2016.
Dr. Soldatos’ expertise relates to pediatric encephalitis, both infectious and immune-mediated. She also has research interests in genomics and clinical trials for rare diseases. She is associate investigator on first-in-human clinical treatment trials including gene therapy for rare childhood neurodegenerative diseases. She is passionate about diversity in leadership and is an alumna of the American Academy of Neurology Women Leading in Neurology program.
Areas of clinical research include:
-NEURO-IMMUNE: CNS histiocytoses, autoimmune encephalitides, genetic autoinflammatory syndromes (NOMID, AGS), neuro-rheumatology, CNS vasculitides including DADA2 syndrome, FIRES/NORSE;
-NEURO-INFECTIOUS: fungal and non-TB mycobacterial CNS infections in children with primary genetic immunodeficiencies;
-NEUROGENETIC: Niemann-Pick type C, Neuronal Ceroid Lipofuscinosis type 3, genetic movement disorders.
Debs S, Ferreira CR, GrodenC, Kim HJ, KingK, KingM, Lehky T, CowenEW, MeridethM, MacnamaraE, Brown LH, ToroC, GahlWA, SoldatosA. Adult diagnosis of congenital serine biosynthesis defect: a treatable cause of progressive neuropathy. American Journal of Medical Genetics Part A 2020.
Schubert RD, Hawes I, Ramachandran PS, Ramesh A, Crawford ED, Pak JE, Wu W, Cheung CK, O’Donovan BD, Tato CM, Lyden A, Tan M, Sit R, Sowa G, Sample HA, Zorn KC, Banerji D, Kahn LM, Bove R, Hauser SL, Gelfand AA, Johnson-Kerner B, Nash K, Krishnamoorthy KS, Chitnis T, Ding JZ, McMillan HJ, Chiu CY, Briggs B, Glaser CA, Yen C, Chu V, Wadford DA, Dominguez SR, Ng TFF, Marine RL, Lopez AS, Nix WA, Soldatos A, Gorman MP, Benson L, Messacar K, Konopka-Anstadt JL, Oberste MS, DeRisi JL, Wilson MR. Pan-Viral Serology Implicates Enteroviruses in Acute Flaccid Myelitis. Nature Medicine 2019.
Ombrello AK, Qin J, Hoffmann P, Kumar P, Stone D, Jones A, Romeo T, Barham B, Pinto-Patarroyo G, Toro C, Soldatos A, Zhou Q, Deuitch N, Aksentijevich I, Sheldon SL, Kelly S, Man A, Barron K, Hershfield M, Flegel AW, Kastner DL. Treatment Strategies for the Deficiency of Adenosine Deaminase 2. NEJM. 2019
Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN. Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation. Blood Advances 2019
Wells E, Hacohen Y, Waldman A, Tillema JM, Soldatos A, Ances B, Benseler S, Bielekova B, Dale RC, Dalmau J, Gaillard W, Gorman M, Greenberg B, Hyslop A, Pardo CA, Tasker RC, Yeh EA, Bar-Or A, Pittock S, Vanderver A, Banwell B. Neuroimmune disorders of the central nervous system in children in the molecular era. Nat Rev Neurol. 2018
Wilson MR, O’Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL. Chronic meningitis investigated via metagenomic next-generation sequencing. JAMA Neurol. 2018
Montealegre Sanchez GA, Reinhardt A, Ramsey S, Wittkowski H, Hashkes PJ, Berkun Y, Schalm S, Murias S, Dare JA, Brown D, Stone DL, Gao L, Klausmeier T, Foell D, Almeida de Jesus A, Chapelle DC, Kim H, Dill S, Colbert RA, Failla L, Kost B, O'Brien M, Reynolds JC, Folio LR, Calvo KR, Paul SM, Weir N, Brofferio A, Soldatos A, Biancotto A, Cowen EW, Digiovanna JG, Gadina M, Lipton AJ, Hadigan C, Holland SM, Fontana J, Alawad AS, Brown RJ, Rother KI, Heller T, Brooks KM, Kumar P, Brooks SR, Waldman M, Singh HK, Nickeleit V, Silk M, Prakash A, Janes JM, Ozen S, Wakim PG, Brogan PA, Macias WL, Goldbach-Mansky R. JAK 1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies. J Clin Invest. 2018
HardeeI*, Soldatos A*, Davids M*, Vilboux T, ToroC, DavidKL, FerreiraCR, NehrebeckyM, Snow J, Thurm A, Heller T, Macnamara EF, Gunay-Aygun M, Zein WM, Gahl WA, Malicdan MCV. Defective ciliogenesis in INPP5E-related Joubert syndrome.*Equal Contribution to first Authorship. Am J Med Genet A. 2017
Kambouris M*, Thevenon J*, Soldatos A*, Cox A, Stephen J, Ben-Omran T, Al-Sarraj Y, Bone W, Mullikin J, Masurel-Paulet A, St-OngeJ, Dufford Y, Chantegret C, Thauvin-Robinet C, Faivre L,Rivière J-B, Gahl WA, Bassuk A, Malicdan MC, El-Shanti H. Biallelic SCN10A mutations in neuromuscular disease and epileptic encephalopathy *Equal Contribution to first Authorship. Annals of Clinical and Translational Neurology 2016
To TM, Soldatos A, Sheriff H, Schmid SD, Espinosa N, Cosentino G, Preas C, Glaser CA. Insights into pediatric herpes simplex encephalitis from a cohort of 22 children from the California Encephalitis Project, 1999-2010. Pediatr Infect Dis J. 2014