NIHBC 35A - PNRC II BG RM 3D-933
35A CONVENT DR
BETHESDA MD 20892
Dr. Amreen Mughal obtained her bachelor’s and master’s degrees in pharmacy from India. After receiving her Ph.D. in Pharmaceutical Sciences from North Dakota State University in 2013, she continued with her postdoctoral work at the University of Vermont in vascular and ion channel physiology. Her postdoctoral work was focused to evaluate mechanisms involved in regulation of blood flow in the brain. Dr. Mughal started her lab at the NIH in 2024. She is a Stadtman Tenure-track Investigator and Chief of the Neurovascular Research Unit in the Stroke branch of the National Institute of Neurological Disorders and Stroke. Her current joint appointment is sponsored by the National Institute of Neurological Disorders and Stroke, and the National Heart, Lung, and Blood Institute.
The Mughal Laboratory (The Neurovascular Research Unit) studies neurovascular coupling mechanisms involved in regulation of blood flow in the brain and clearance of metabolic by-products. Along with providing basic understanding of these mechanisms in physiology, the research also extends to the vascular cognitive impairment and dementia (VCID) including stroke and Alzheimer’s disease. By using pre-clinical models and cutting-edge imaging approaches, the Mughal laboratory provides a thorough understanding of different neurovascular mechanisms along with the contributions of different vascular compartments (pial arteries-arterioles-capillaries-venules-pial vein) with the aim to extend this knowledge from physiology to disease models.
Learn more about our research: https://research.ninds.nih.gov/mughal-lab
A Mughal*, AM Sackheim*, M Koide, G Bonson, G Ebner, G Hennig, W Lockette, MT Nelson, K Freeman (2024)
Pathogenic soluble tau peptide disrupts endothelial calcium signaling and vasodilation in the brain microvasculature.
JCBFM, In-Press, PubMed ID: 38420777
Mughal A, Nelson MT, Hill-Eubanks D (2023)
The post-arteriole transitional zone: a specialized capillary region that regulates blood flow within the CNS microvasculature.
J Physiol, 601:889-901. PubMed ID: 36751860
Sancho M, Klug NR, Mughal A, Koide M, Huerta de la Cruz S, Heppner TJ, Bonev AD, Hill-Eubanks D, Nelson MT (2022)
Adenosine signaling activates ATP-sensitive K+ channels in endothelial cells and pericytes in CNS capillaries.
Sci Signal, 15:eabl5405. PubMed ID: 35349300
Longden TA*, Mughal A*, Hennig GW*, Harraz OF, Shui B, Lee FK, Lee JC, Reining S, Kotlikoff MI, König GM, Kostenis E, Hill-Eubanks D, Nelson MT (2021)
Local IP3 receptor-mediated Ca2+ signals compound to direct blood flow in brain capillaries.
Sci Adv, 7 PubMed ID: 34290098
* Equal contributions as the first authors.
For a full list of publications, please visit PubMed.