Tenure Seminar: Defining the Genetic Architecture of Lewy Body Dementia and Related Disorders

Wednesday, June 21, 2023 | 12:00 - 1:00 PM

 Location: Porter Neuroscience Bldg., Room 620/630

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Sonja W. Scholz, M.D., Ph.D.
Sonja W. Scholz, M.D., Ph.D.
Lasker Clinical Research Scholar
Neurodegenerative Diseases Research Unit

Research Topics

Advances in genomic technologies have provided us with unprecedented capabilities to explore heritable factors involved in the development of neurological diseases. Neurogenetics has already revolutionized how we think about common neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

We extend these powerful genomic techniques to other neurodegenerative diseases, such as Lewy body dementia, multiple system atrophy, frontotemporal dementia, progressive supranuclear palsy, and corticobasal degeneration. The Neurodegenerative Diseases Research Unit (NDRU) has been established to achieve this aim. NDRU is integrated within the Laboratory of Neurogenetics, a leader in this field over the last decade. Its primary mission is to unravel molecular genetic mechanisms that cause these devastating diseases. This knowledge identifies targets for drug development. To maximize our impact, we are building on our national and international collaborations, and we leverage the unique resources within the Intramural Research Program at the NIH.