Dr. Yuxiang Xie received his Ph.D. degree of Biophysics from Chinese Academy of Science in 2006, where he worked in Dr. Baolu Zhao’s lab to study the preventive role of nature antioxidant on neurodegenerative diseases, including Parkinson’s disease and Alzheimer’s disease.
During his postdoctoral fellowship in Dr. Baoji Xu’s lab at Georgetown University, he investigated the effects of neurotrophic factors in Huntington’s disease and in neuronal development. Dr. Xie then joined Dr. Zu-Hang Sheng’s lab in NINDS as a research fellow in 2010 and is now a Staff Scientist of the Synaptic Function Section.
His current works focused on how the dysfunction and altered transport of mitochondria, and the defective autophagy-lysosomal function have been implicated in the pathogenesis of several major neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis, Parkinson’s disease and Lysosome storage diseases.
The focus of Dr. Yuxiang Xie’s research is on the neurodegenerative mechanisms underlying Amyotrophic Lateral Sclerosis, Parkinson’s disease and other neurodegenerative diseases. His current works focused on the following fundamental issues: (1) Role of neurotrophins in neuronal development and in neurodegenerative diseases; (2) How the autophagy-lysosome pathway is regulated in neurodegenerative diseases; and (3) How mitochondria activity and mitophagy in neurons regulate neuronal development, function and survival.