Positions available for Intramural Training Awards (< 3 years from degree). Lab focuses on mechanisms directing development and regulation of the GnRH neuroendocrine cells which arise in olfactory regions and migrate into the brain, where they control reproductive function. Developmental research addresses Cell lineage, Neuronal Migration, Axonal Targeting, Craniofacial development and Understanding mutations identified in patients with Kallmann Syndrome. Candidates with experience in mouse development, molecular and imaging techniques preferred. To understand the mechanisms underlying GnRH neuronal activity, primary GnRH neurons in explants, slice cultures and whole animals are assayed to study the molecular and cellular properties of neuronal activity (individual cells and neuronal population dynamics) and correlate activity with secretion. Candidates with experience in calcium imaging or electrophysiology, molecular biology and mouse anatomy preferred.
- Shan, Y. Farmer, SM, Wray, S. Drebrin Regulates Cytoskeleton Dynamics in Migrating Neurons through Interaction with CXCR4. PNAS, 2021.
- Constantin S, Reynolds, D. Oh, A, Pizano K, Wray S. Nitric oxide resets kisspeptin-excited GnRH neurons via PIP2 replenishment. PNAS, 2021.
Please send a letter describing your interest and long term goals, a curriculum vitae and three letters of reference to:
Susan Wray, Ph.D.
Cellular and Developmental Neurobiology Section, NINDS, NIH
Porter Neuroscience Research Center
35 Convent Drive 35, 3A-1012
Bethesda, MD 20892-3703
Office: (301) 496-6646
Fax: (301) 496-8578
Lab : (301) 496-8129
NIH AND DHHS ARE EQUAL OPPORTUNITY EMPLOYERS