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With our laboratory and clinical studies, our team aims to modulate the tumor microenvironment to enhance effective treatments to the CNS for malignant gliomas. Our laboratory studies include use of BBB models and preclinical explorations with aggressive pediatric/young adult glioma cells. Using intracerebral microdialysis within tumor tissue and surrounding regions, we are able to evaluate optimal drug entry to malignant tumors. These exquisite tools help to measure drug concentrations, along with agents to transiently disrupt the BBB, to maximize therapies for prolonged survival in pediatric brain tumors with poor prognoses.