Dr. Chittiboina earned his M.D. from Goa University (India) in 2000 and a Master of Public Health from Idaho State University in 2004. He completed his residency in neurosurgery at Louisiana State University in 2012. During his residency, Dr. Chittiboina also completed a year-long research fellowship studying neuro-vascular disease. He came to NINDS in 2012 as a translational research fellow, becoming a Staff Clinician in the Surgical Neurology Branch in 2013. He became an Assistant Clinical Investigator in 2015 and a Tenure Track Investigator in 2020. His laboratory studies neurosurgical disorders of the pituitary gland and inheritable tumor syndromes. His current work is focused on improving the outcomes of neurosurgical disorders through translational research approaches.
The emphasis of my unit is translational research to address challenging clinical problems . Using precious surgical tissues, my group performs transcriptomic, epigenomic and functional mapping of central nervous system tumors. A detailed map of the transcriptome and epigenome in pituitary and inheritable tumors is generating hypotheses and is improving our understanding of underlying pathogenic mechanisms. We have also successfully applied these findings back to the clinical realm with clinical trials in metabolic imaging and targeted therapy of central nervous system tumors.
- Debjani Mandal, PhD. Scientist.
- David Asuzu, MD, PhD, PGY4 Neurosurgery Resident, NIH-UVA Program. Post-doc.
- Emma Celano, MD, PGY4 Neurosurgery Resident, Georgetown University. Collaborator.
- Elizabeth Hogan, MD, PGY6 Neurosurgery Resident, George Washington University. Collaborator.
- Diana Nwokoye, BS, Howard Medical School. MRSP.
- Bright Wiafe, BS. Post-bac IRTA.
- Stefan Stoica, BS. Post-bac IRTA.
- Anish Kosanam, BS. Post-bac IRTA.
- Maytal Silberberg, BS. Post-bac IRTA.
- Reinier Alvarez, BS, Florida International University Medical School. Special Volunteer.
1: Nelson CN, Dombi E, Rosenblum JS, Miettinen MM, Lehky TJ, Whitcomb PO, Hayes C, Scott G, Benzo S, Widemann BC, Chittiboina P. Safe marginal resection of atypical neurofibromas in neurofibromatosis type 1. J Neurosurg. 2019 Oct 25:1-11. doi: 10.3171/2019.7.JNS191353. Epub ahead of print. PMID: 31653805.
2: Alvarez R, Mastorakos P, Hogan E, Scott G, Lonser RR, Wiley HE, Chew EY, Chittiboina P. Retrobulbar Hemangioblastomas in von Hippel-Lindau Disease: Clinical Course and Management. Neurosurgery. 2021 Jan 13:nyaa565. doi: 10.1093/neuros/nyaa565. Epub ahead of print. PMID: 33442737.
3: Boyle J, Patronas NJ, Smirniotopoulos J, Herscovitch P, Dieckman W, Millo C, Maric D, Chatain GP, Hayes CP, Benzo S, Scott G, Edwards N, Ray Chaudhury A, Lodish MB, Sharma S, Nieman LK, Stratakis CA, Lonser RR, Chittiboina P. CRH stimulation improves 18F-FDG-PET detection of pituitary adenomas in Cushing's disease. Endocrine. 2019 Jul;65(1):155-165. doi: 10.1007/s12020-019-01944-7. Epub 2019 May 6. PMID: 31062234.
4: Ironside N, Chatain G, Asuzu D, Benzo S, Lodish M, Sharma S, Nieman L, Stratakis CA, Lonser RR, Chittiboina P. Earlier post-operative hypocortisolemia may predict durable remission from Cushing's disease. Eur J Endocrinol. 2018 Mar;178(3):255-263. doi: 10.1530/EJE-17-0873. Epub 2018 Jan 12. PMID: 29330227; PMCID: PMC5812811.
5: Lu J, Montgomery BK, Chatain GP, Bugarini A, Zhang Q, Wang X, Edwards NA, Ray-Chaudhury A, Merrill MJ, Lonser RR, Chittiboina P. Corticotropin releasing hormone can selectively stimulate glucose uptake in corticotropinoma via glucose transporter 1. Mol Cell Endocrinol. 2018 Jul 15;470:105-114. doi: 10.1016/j.mce.2017.10.003. Epub 2017 Oct 3. PMID: 28986303; PMCID: PMC5882598.