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“Arbor Vitae,” colorized image from formalin fixed human cerebellum acquired at 100 micron isotropic resolution on the 11.7T MRI system. Image credit: Govind Nair Bhagavatheeshwaran), Staff Scientist in the qMRI Core Facility, and Stephen Dodd, Staff Scientist, at the Laboratory of Functional and Molecular Imaging.

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ER Reads the Tubulin Code to Navigate the Cell

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Image Credit: Dr. William Grimes. Description: Dendro-somatic synaptic contact between an inhibitory interneuron (magenta) and a retinal ganglion cell (yellow). These synaptic contacts, described in Grimes et al., 2021, convey high-sensitivity visual signals under low light conditions. In the dark, a sustained OFFα ganglion cell transmits a steady train of action potentials down its axon (white arrow). Dim light stimuli activate the interneuron, which inhibits the OFFα soma and interrupts spiking.

Retinal Neurons Convey Sensitive Information under Cover of Darkness

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Florescent micrograph of SPTLC1-mutant motor-neuron-like cells differentiated from SPTLC1-mutant induced pluripotent stem cells, immunostained with relevant markers.

A New Genetic Form of ALS in Children

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Cerebellospinal Neurons Regulate Motor Performance and Motor Learning

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About NINDS Division of Intramural Research

The present Intramural Research program of the National Institute of Neurological Disorders and Stroke (NINDS) began in the early 1950's with research programs in basic neuroscience, neurology and neurosurgery. Today investigators in the NINDS intramural program conduct research in the basic, translational, and clinical neurosciences at the NINDS Bethesda, Maryland laboratories.

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Upcoming Events

Friday, May 20, 2022 | 2:00 - 3:00 PM
Training/Career Development Focus: Speaking about Science Workshop
A professional development workshop about giving good scientific talks
Monday, May 23, 2022 | 12:00 - 1:00 PM
Neuroscience Seminar Series: Synaptic Functions of Neurodevelopmental Disorder Risk Molecules
Peter Penzes, Ph.D. Northwestern University
Wednesday, May 25, 2022 | 12:00 - 12:30 PM
Training/Career Development Focus: Informational Interviewing Session
A professional development session on how to use informational interviews to your benefit, to explore various career paths and as networking…
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NINDS Intramural Spotlight
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Fellows in Focus
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NINDS in the Press